The normal function of articular cartilage is to protect the bone and to ensure that there is adequate slide, as well as dissipation and amortization of existing forces during loading phases. Articular cartilage is constantly exposed to mechanical stress, which is vital to its health. Loss of the ability to respond to pressure and to any metabolic alterations caused by it results in degeneration, as observed in osteoarthritis.
The cartilage consists of chondrocytes, intercellular ground substance, collagen fibers and proteoglycans.
Articular fluid is a yellowish viscous liquid that fills the articular cavity. It is a product of plasma ultrafiltration, containing various substances and hyaluronic acid. Its main functions are nutritional support and cartilage lubrication, in addition to absorption of vibration. The role of synovial fluid as a shock absorber contributes to the protection of bones and cartilage from stress developed during movement, walking, running, etc.
Hyaluronic acid is produced by chondrocytes and synovial cells and is released into the synovial joint. It penetrates into the superficial layer of both cartilage and synovial membrane, thus creating a protective coating against mechanical injuries and chemical irritation.
In the case of osteoarthritis, the elasticity and viscosity of the synovial fluid are significantly lower compared to a normal joint. One important cause is a decrease in the molecular weight and concentration of hyaluronic acid, thereby reducing its “lubricant”, protective effect. When this is diminished, any weight pressure as a result of normal movement causes damage to both cartilage surface and synovial membrane.
Enhancing viscoelasticity with hyaluronic acid is a safe, effective, and well-established option in the treatment of osteoarthritis symptoms, and involves injecting a certain quantity of hyaluronic acid solution into the affected joint.
Exogenous administration of hyaluronic acid activates synovial cells to produce native hyaluronic acid and provides the structural backbone of proteoglycans. At the same time, the number of inflammatory cells is reduced, while the number of free radicals and peroxides is brought under control.
Chondryal plus is a viscoelasticity enhancing product, containing a unique combination of sodium hyaluronate 60mg/3ml and chondroitin sodium sulphate 90mg/3ml in a pre-filled syringe. The combination is one of a kind, and it is the first to be released in Greece. The estimated duration of action for Chondryal plus is approximately one year.
Administration of Sodium hyaluronate provides symptomatic relief in osteoarthritis by restoring synovial fluid viscoelasticity and by stimulating hyaluronic acid production in the synovial membrane.
Chondroitin sulfate is fundamental to the structural and functional integrity of the joints, as it constitutes the majority of articular cartilage glycosaminoglycans. Chondroitin sulfate stimulates the synthesis of proteoglycans from chondrocytes and inhibits the production of substances that cause early cartilage fraying and degradation. It also stimulates the high molecular weight synthesis of hyaluronic acid.
The unique combination of the two substances can further improve therapeutic efficacy and offers:
- Pain relief
- Motility & mobility improvement
- Cartilage protection
